Systemic Antifungal Activity of Pyrrolnitrin
نویسندگان
چکیده
منابع مشابه
Mechanism of action of the antifungal antibiotic pyrrolnitrin.
Pyrrolnitrin at 10 mug/ml inhibited the growth of Saccharomyces cerevisiae, Penicillium atrovenetum, and P. oxalicum. The primary site of action of pyrrolnitrin on S. cerevisiae was the terminal electron transport system between succinate or reduced nicotinamide adenine dinucleotide (NADH) and coenzyme Q. At growth inhibitory concentrations, pyrrolnitrin inhibited endogenous and exogenous respi...
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Pyrrolnitrin inhibits the syntheses of protein, RNA and DNA to almost the samedegree. It also inhibits respiration but this site does not seem to be the primary action. It does not inhibit the biosynthesis of porphyrin. It is not an uncoupler of oxidative phosphorylation. It inhibits the transport of many substances, and causes the leakage of A260m^ absorbing materials inside the cells. Pyrroln...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1969
ISSN: 0003-6919
DOI: 10.1128/am.17.5.690-694.1969